Secondary Nucleation by Interparticle Energies. I. Thermodynamics

Secondary nucleation, in the absence of attrition, is known to be dependent on external fields, such as contact forces, shear, or interparticle forces. In this contribution, thermodynamic effect presence seed crystal surface secondary nucleation derived context classical theory. The Gibbs free energy for formation a cluster close calculated with addition energies, namely, van der Waals attractive forces and Born repulsive This results stabilization subcritical that can become nucleus more easily than under homogeneous conditions. Far from surface, developed model reduced described by crystallization paracetamol an ethanol solution taken case study, effect, given observed at different values supersaturation. Three key indicators have been defined describe intensity two which, distance where active enhancement factor supersaturation, are used Part II series kinetics energies.